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Cardioimmunology · Book 2

The Method, Cardioimmunology. Book 2

Understanding Evidence and Building Knowledge in Cardioimmunology

Brahim Abdelouaeb ORCID 0009-0002-7690-9993

Lire l’édition originale française de La Méthode · About the author · About cardioimmunology

Read online Download the PDF Zenodo · doi:10.5281/zenodo.23271825
FIRST EDITION · 2026EVIDENCE · INTERPRETATION · JUDGMENTTHE CARDIOIMMUNOLOGY COLLECTION
THE ARGUMENT

About the book

The Method is Book 2 of the Cardioimmunology collection. The Treatise on Cardioimmunology is in preparation. It examines how knowledge is built in cardioimmunology: how a result supports a proposition, how a cause is established, how sources are read and evidence is constructed. It also shows how a conclusion can be kept, restricted or revised.

The book moves from the foundations of medical knowledge to inflammation and experimental models, the testing of hypotheses through treatments, including the lessons of negative trials, the connections between systems and measurements and the formation and transmission of medical judgment.

The book includes a methodological analysis of the 2025 guidelines of the European Society of Cardiology. Each commentary distinguishes what is established, what remains plausible and what cannot be concluded.

A PLURAL READING

Four readings for each text

Critical reading
What does the comparison allow?
Measures, bias, uncertainty
Immunological reading
What is the explanation worth?
Mechanism, context, alternatives
Cardiological reading
What scope for the heart?
Diagnosis, prognosis, treatment
Integrative clinical reading
What does it change for the person?
Priorities, other diseases, care pathway
Judgment common to the four readings: keep, restrict or revise the conclusion.
THE INTELLECTUAL JOURNEY

Contents

Part IBuilding Knowledge of Living Systems
  1. Knowing in Medicine
  2. Defining Health and Disease
  3. Explaining and Establishing a Cause
  4. Reading Sources and Building the Evidence
Part IIUnderstanding Mechanisms and Testing Models
  1. Inflammation between Protection and Disease
  2. The Heart as an Immune Milieu
  3. Atherosclerosis and the Convergence of Evidence
  4. Repair and the Limits of Experimental Models
Part IIITesting Hypotheses through Treatments
  1. Coronary Inflammation Put to the Test in Trials
  2. Pericarditis and Myocarditis as Testing Grounds for Clinical Experimentation
  3. Systemic Diseases and the Question of Extrapolation to the Heart
  4. Heart Failure and the Lessons of Negative Trials
  5. Infiltrative Cardiomyopathies and the Specificity of Treatments
Part IVConnecting Systems and Interpreting Measurements
  1. The Heart in Its Relations with the Microbiota and Infection
  2. Immune Treatments as Revealers of Disease
  3. Precision Medicine between Measurement and Interpretation
  4. Transplantation and the Knowledge of Rejection
Part VForming and Transmitting Medical Judgment
  1. What Numbers Allow One to Conclude
  2. From the Study Population to the Person Receiving Care
  3. Objectivity as Collective Work
  4. The Responsibility to Know and to Transmit

The edition

Author
Dr Brahim Abdelouaeb, author and scientific editor
Edition
First edition, 2026. Digital edition
Language
English translation of the French edition, La Méthode, which remains the reference text
DOI
10.5281/zenodo.23271825
License
CC BY-NC-ND 4.0
Collection
Book 1, the treatise Cardioimmunology, is in preparation; its architecture is published on Zenodo

Status of the text

This is a book of method. It is neither a guideline of a learned society nor an enforceable standard. The current guidelines of learned societies remain the sole authority for therapeutic decisions. Examples presented as fictional are entirely fictional.

Disclosure of interests. The author declares relationships with GSK, AstraZeneca, Lilly and Menarini, limited to invitations to meals at product presentations. The book received no external funding. Its integrity charter is printed at the beginning of the book.

How to cite. Abdelouaeb B. The Method, Cardioimmunology. Book 2: Understanding Evidence and Building Knowledge in Cardioimmunology. Brahim Abdelouaeb; 2026. doi:10.5281/zenodo.23271825

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